Autism spectrum disorders are a group of neuro-developmental conditions characterized by varying degrees of language impairment, including verbal and non-verbal communication, impaired social skill, and repetitive behaviors. In this paper, we review the evidence for an association between autism and thiamine. A relationship between thiamine status and the development of autism has been established, with thiamine supplementation exhibiting a beneficial clinical effect on children with autism. Thiamine may involve in autism via apoptotic factors (transcription factor p53, Bcl-2, and caspase-3), neurotransmitter systems (serotonin, acetylcholine, and glutamate), and oxidative stress (prostaglandins, cyclooxygenase-2, reactive oxygen species, nitric oxide synthase, the reduced form of nicotinamide adenine dinucleotide phosphate, and mitochondrial dysfunction). In addition, thiamine has also been implicated in autism via its effects on basic myelin protein, glycogen synthetase kinase-3β, alpha-1 antitrypsin, and glyoxalase 1. Thiamine may play a role in children with autism. Additional investigation of thiamine in children with autism is needed.
| Published in | American Journal of Psychiatry and Neuroscience (Volume 1, Issue 2) |
| DOI | 10.11648/j.ajpn.20130102.11 |
| Page(s) | 22-37 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2013. Published by Science Publishing Group |
Thiamine, Autism, Vitamin B1, Transketolase
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APA Style
Khanh vinh quốc Lương, Lan Thi Hoàng Nguyễn. (2013). The Role of Thiamine in Autism. American Journal of Psychiatry and Neuroscience, 1(2), 22-37. https://doi.org/10.11648/j.ajpn.20130102.11
ACS Style
Khanh vinh quốc Lương; Lan Thi Hoàng Nguyễn. The Role of Thiamine in Autism. Am. J. Psychiatry Neurosci. 2013, 1(2), 22-37. doi: 10.11648/j.ajpn.20130102.11
AMA Style
Khanh vinh quốc Lương, Lan Thi Hoàng Nguyễn. The Role of Thiamine in Autism. Am J Psychiatry Neurosci. 2013;1(2):22-37. doi: 10.11648/j.ajpn.20130102.11
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Download@article{10.11648/j.ajpn.20130102.11,
author = {Khanh vinh quốc Lương and Lan Thi Hoàng Nguyễn},
title = {The Role of Thiamine in Autism},
journal = {American Journal of Psychiatry and Neuroscience},
volume = {1},
number = {2},
pages = {22-37},
doi = {10.11648/j.ajpn.20130102.11},
url = {https://doi.org/10.11648/j.ajpn.20130102.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20130102.11},
abstract = {Autism spectrum disorders are a group of neuro-developmental conditions characterized by varying degrees of language impairment, including verbal and non-verbal communication, impaired social skill, and repetitive behaviors. In this paper, we review the evidence for an association between autism and thiamine. A relationship between thiamine status and the development of autism has been established, with thiamine supplementation exhibiting a beneficial clinical effect on children with autism. Thiamine may involve in autism via apoptotic factors (transcription factor p53, Bcl-2, and caspase-3), neurotransmitter systems (serotonin, acetylcholine, and glutamate), and oxidative stress (prostaglandins, cyclooxygenase-2, reactive oxygen species, nitric oxide synthase, the reduced form of nicotinamide adenine dinucleotide phosphate, and mitochondrial dysfunction). In addition, thiamine has also been implicated in autism via its effects on basic myelin protein, glycogen synthetase kinase-3β, alpha-1 antitrypsin, and glyoxalase 1. Thiamine may play a role in children with autism. Additional investigation of thiamine in children with autism is needed.},
year = {2013}
}
TY - JOUR T1 - The Role of Thiamine in Autism AU - Khanh vinh quốc Lương AU - Lan Thi Hoàng Nguyễn Y1 - 2013/09/10 PY - 2013 N1 - https://doi.org/10.11648/j.ajpn.20130102.11 DO - 10.11648/j.ajpn.20130102.11 T2 - American Journal of Psychiatry and Neuroscience JF - American Journal of Psychiatry and Neuroscience JO - American Journal of Psychiatry and Neuroscience SP - 22 EP - 37 PB - Science Publishing Group SN - 2330-426X UR - https://doi.org/10.11648/j.ajpn.20130102.11 AB - Autism spectrum disorders are a group of neuro-developmental conditions characterized by varying degrees of language impairment, including verbal and non-verbal communication, impaired social skill, and repetitive behaviors. In this paper, we review the evidence for an association between autism and thiamine. A relationship between thiamine status and the development of autism has been established, with thiamine supplementation exhibiting a beneficial clinical effect on children with autism. Thiamine may involve in autism via apoptotic factors (transcription factor p53, Bcl-2, and caspase-3), neurotransmitter systems (serotonin, acetylcholine, and glutamate), and oxidative stress (prostaglandins, cyclooxygenase-2, reactive oxygen species, nitric oxide synthase, the reduced form of nicotinamide adenine dinucleotide phosphate, and mitochondrial dysfunction). In addition, thiamine has also been implicated in autism via its effects on basic myelin protein, glycogen synthetase kinase-3β, alpha-1 antitrypsin, and glyoxalase 1. Thiamine may play a role in children with autism. Additional investigation of thiamine in children with autism is needed. VL - 1 IS - 2 ER -
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