Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model

Sahar Mohamed Kamal Shams El Dine

doi:doi:10.11648/j.ajpn.20140204.11

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Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model

Sahar Mohamed Kamal Shams El Dine

Published in American Journal of Psychiatry and Neuroscience (Volume 2, Issue 4)

Received: 9 August 2014 Accepted: 23 August 2014 Published: 10 September 2014

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Abstract

The present study is designed to investigate the possible hepatotoxic effects of the anti-epileptic drug “lamotrigine, LTG” in adult male wister rats after picrotoxin –induced convulsions and exposure for 21 days to chronic restraint model. This was done by a trial to find out alterations in the activities of liver enzymes and some antioxidants in this model of co-morbidity. They were treated by gastric gavage with LTG [20mg/kg body wt.] for 21days. Then rats were anesthetized and dissected to remove liver and to collect blood. Selected liver enzymes [AST, ALT] and some anti-oxidant enzymes were assayed. The results indicated that the drug significantly increased the activities of glutathione peroxidase and catalase enzymes in hepatic homogenates, while it significantly decreased the level of the lipid peroxidation expressed as thiobarbituric acid-reactive substance (TBARS) in these homogenates. However, there was an elevation of tested liver enzymes ALT & AST at the end of 21 days. This revealed the occurrence of possible hepatocellular damage. The present study recommends a regular liver function and drug monitoring during the therapeutic use of this drug in epilepsy-stress co-morbidity.

Published in	American Journal of Psychiatry and Neuroscience (Volume 2, Issue 4)
DOI	10.11648/j.ajpn.20140204.11
Page(s)	50-55
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Lamotrigine, Picrotoxin, Chronic Restraint Model, Liver, Rats

References

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Sahar Mohamed Kamal Shams El Dine. (2014). Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model. American Journal of Psychiatry and Neuroscience, 2(4), 50-55. https://doi.org/10.11648/j.ajpn.20140204.11

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ACS Style

Sahar Mohamed Kamal Shams El Dine. Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model. Am. J. Psychiatry Neurosci. 2014, 2(4), 50-55. doi: 10.11648/j.ajpn.20140204.11

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AMA Style

Sahar Mohamed Kamal Shams El Dine. Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model. Am J Psychiatry Neurosci. 2014;2(4):50-55. doi: 10.11648/j.ajpn.20140204.11

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@article{10.11648/j.ajpn.20140204.11,
  author = {Sahar Mohamed Kamal Shams El Dine},
  title = {Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {2},
  number = {4},
  pages = {50-55},
  doi = {10.11648/j.ajpn.20140204.11},
  url = {https://doi.org/10.11648/j.ajpn.20140204.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20140204.11},
  abstract = {The present study is designed to investigate the possible hepatotoxic effects of the anti-epileptic drug “lamotrigine, LTG” in adult male wister rats after picrotoxin –induced convulsions and exposure for 21 days to chronic restraint model. This was done by a trial to find out alterations in the activities of liver enzymes and some antioxidants in this model of co-morbidity. They were treated by gastric gavage with LTG [20mg/kg body wt.] for 21days. Then rats were anesthetized and dissected to remove liver and to collect blood. Selected liver enzymes [AST, ALT] and some anti-oxidant enzymes were assayed. The results indicated that the drug significantly increased the activities of glutathione peroxidase and catalase enzymes in hepatic homogenates, while it significantly decreased the level of the lipid peroxidation expressed as thiobarbituric acid-reactive substance (TBARS) in these homogenates. However, there was an elevation of tested liver enzymes ALT & AST at the end of 21 days. This revealed the occurrence of possible hepatocellular damage. The present study recommends a regular liver function and drug monitoring during the therapeutic use of this drug in epilepsy-stress co-morbidity.},
 year = {2014}
}

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TY  - JOUR
T1  - Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model
AU  - Sahar Mohamed Kamal Shams El Dine
Y1  - 2014/09/10
PY  - 2014
N1  - https://doi.org/10.11648/j.ajpn.20140204.11
DO  - 10.11648/j.ajpn.20140204.11
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 50
EP  - 55
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20140204.11
AB  - The present study is designed to investigate the possible hepatotoxic effects of the anti-epileptic drug “lamotrigine, LTG” in adult male wister rats after picrotoxin –induced convulsions and exposure for 21 days to chronic restraint model. This was done by a trial to find out alterations in the activities of liver enzymes and some antioxidants in this model of co-morbidity. They were treated by gastric gavage with LTG [20mg/kg body wt.] for 21days. Then rats were anesthetized and dissected to remove liver and to collect blood. Selected liver enzymes [AST, ALT] and some anti-oxidant enzymes were assayed. The results indicated that the drug significantly increased the activities of glutathione peroxidase and catalase enzymes in hepatic homogenates, while it significantly decreased the level of the lipid peroxidation expressed as thiobarbituric acid-reactive substance (TBARS) in these homogenates. However, there was an elevation of tested liver enzymes ALT & AST at the end of 21 days. This revealed the occurrence of possible hepatocellular damage. The present study recommends a regular liver function and drug monitoring during the therapeutic use of this drug in epilepsy-stress co-morbidity.
VL  - 2
IS  - 4
ER  -

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Author Information

Sahar Mohamed Kamal Shams El Dine

Department of Pharmacology, Faculty of Medicine, University of Ain-Shams, Cairo, Egypt

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APA Style

Sahar Mohamed Kamal Shams El Dine. (2014). Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model. American Journal of Psychiatry and Neuroscience, 2(4), 50-55. https://doi.org/10.11648/j.ajpn.20140204.11

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ACS Style

Sahar Mohamed Kamal Shams El Dine. Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model. Am. J. Psychiatry Neurosci. 2014, 2(4), 50-55. doi: 10.11648/j.ajpn.20140204.11

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AMA Style

Sahar Mohamed Kamal Shams El Dine. Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model. Am J Psychiatry Neurosci. 2014;2(4):50-55. doi: 10.11648/j.ajpn.20140204.11

Copy | Download

@article{10.11648/j.ajpn.20140204.11,
  author = {Sahar Mohamed Kamal Shams El Dine},
  title = {Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {2},
  number = {4},
  pages = {50-55},
  doi = {10.11648/j.ajpn.20140204.11},
  url = {https://doi.org/10.11648/j.ajpn.20140204.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20140204.11},
  abstract = {The present study is designed to investigate the possible hepatotoxic effects of the anti-epileptic drug “lamotrigine, LTG” in adult male wister rats after picrotoxin –induced convulsions and exposure for 21 days to chronic restraint model. This was done by a trial to find out alterations in the activities of liver enzymes and some antioxidants in this model of co-morbidity. They were treated by gastric gavage with LTG [20mg/kg body wt.] for 21days. Then rats were anesthetized and dissected to remove liver and to collect blood. Selected liver enzymes [AST, ALT] and some anti-oxidant enzymes were assayed. The results indicated that the drug significantly increased the activities of glutathione peroxidase and catalase enzymes in hepatic homogenates, while it significantly decreased the level of the lipid peroxidation expressed as thiobarbituric acid-reactive substance (TBARS) in these homogenates. However, there was an elevation of tested liver enzymes ALT & AST at the end of 21 days. This revealed the occurrence of possible hepatocellular damage. The present study recommends a regular liver function and drug monitoring during the therapeutic use of this drug in epilepsy-stress co-morbidity.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Possible Effects of Lamotrigine on Liver of Wister Rats Exposed to Chemoconvulsion and Chronic Restraint Model
AU  - Sahar Mohamed Kamal Shams El Dine
Y1  - 2014/09/10
PY  - 2014
N1  - https://doi.org/10.11648/j.ajpn.20140204.11
DO  - 10.11648/j.ajpn.20140204.11
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 50
EP  - 55
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20140204.11
AB  - The present study is designed to investigate the possible hepatotoxic effects of the anti-epileptic drug “lamotrigine, LTG” in adult male wister rats after picrotoxin –induced convulsions and exposure for 21 days to chronic restraint model. This was done by a trial to find out alterations in the activities of liver enzymes and some antioxidants in this model of co-morbidity. They were treated by gastric gavage with LTG [20mg/kg body wt.] for 21days. Then rats were anesthetized and dissected to remove liver and to collect blood. Selected liver enzymes [AST, ALT] and some anti-oxidant enzymes were assayed. The results indicated that the drug significantly increased the activities of glutathione peroxidase and catalase enzymes in hepatic homogenates, while it significantly decreased the level of the lipid peroxidation expressed as thiobarbituric acid-reactive substance (TBARS) in these homogenates. However, there was an elevation of tested liver enzymes ALT & AST at the end of 21 days. This revealed the occurrence of possible hepatocellular damage. The present study recommends a regular liver function and drug monitoring during the therapeutic use of this drug in epilepsy-stress co-morbidity.
VL  - 2
IS  - 4
ER  -

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