Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients

Waleed Omar; Mohammad Hamed; Sabry Ahmed Mahmoud; Hosam Elbanna; Mahmoud Abdelnaby; Sameh Emile; Mohamed Anwar

doi:doi:10.11648/j.js.20180602.13

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Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients

Waleed Omar, Mohammad Hamed, Sabry Ahmed Mahmoud, Hosam Elbanna, Mahmoud Abdelnaby, Sameh Emile, Mohamed Anwar

Published in Journal of Surgery (Volume 6, Issue 2)

Received: 6 February 2018 Accepted: 24 February 2018 Published: 19 March 2018

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Abstract

Bariatric surgery proved effective in the treatment of morbid obesity and its associated comorbidities. The aim of this study was to assess weight loss and changes in glucose homeostasis and satiety hormones and to evaluate improvement in diabetic status in morbidly obese patients with type two diabetes mellitus (T2DM) at 6 and 12 months after laparoscopic greater curvature plication (LGCP). Twenty patients with morbid obesity with T2DM were operated upon with LGCP. Weight loss was assessed by the decrease in BMI and percentage of excess weight loss at 6 and 12 months after LGCP. Fasting and postprandial blood glucose levels, HbA1c, fasting serum insulin, serum ghrelin and glucagon-like peptide 1 (GLP-1) levels were measured before and at 6 and 12 months postoperatively. The mean age of patients was 37.6 years. There was significant decrease in BMI from 45.4 to 40.1 at 6 months (p= 0.0008) and then to 36.4 at 12 month (p< 0.0001). The mean fasting blood glucose decreased significantly from 134.8 preoperatively to 120.8 at 6 months (p< 0.0001) and then to 109.5 at 12 months (p< 0.0001). The mean preoperative HbA1c declined from 6.8 before LGCO to 6.3 at 6 months (p< 0.0001) then to 5.9 at 12 months (p< 0.0001). The mean fasting insulin level decreased from 20.5 preoperatively to 17.4 at 6 months (p< 0.0001) then to 16.7 at 12 months (p< 0.0001). The mean baseline ghrelin level decreased significantly from 551.7 preoperatively to 441.5 at 6 months (p< 0.0001) then to 422.5 at 12 months (p< 0.0001). The mean GLP-1 declined from 33.7 before surgery to 33.5 at 6 months (p= 0.76) then to 33.1 at 12 months (p= 0.36). LGCP is an effective bariatric procedure that achieved satisfactory weight loss and significant improvement in the glycemic control as demonstrated by improvement in laboratory markers as serum glucose, insulin, and ghrelin hormone levels.

Published in	Journal of Surgery (Volume 6, Issue 2)
DOI	10.11648/j.js.20180602.13
Page(s)	43-49
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Laparoscopic, Greater Curvature, Plication, Diabetes, Obesity

References

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APA Style

Waleed Omar, Mohammad Hamed, Sabry Ahmed Mahmoud, Hosam Elbanna, Mahmoud Abdelnaby, et al. (2018). Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients. Journal of Surgery, 6(2), 43-49. https://doi.org/10.11648/j.js.20180602.13

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ACS Style

Waleed Omar; Mohammad Hamed; Sabry Ahmed Mahmoud; Hosam Elbanna; Mahmoud Abdelnaby, et al. Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients. J. Surg. 2018, 6(2), 43-49. doi: 10.11648/j.js.20180602.13

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AMA Style

Waleed Omar, Mohammad Hamed, Sabry Ahmed Mahmoud, Hosam Elbanna, Mahmoud Abdelnaby, et al. Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients. J Surg. 2018;6(2):43-49. doi: 10.11648/j.js.20180602.13

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@article{10.11648/j.js.20180602.13,
  author = {Waleed Omar and Mohammad Hamed and Sabry Ahmed Mahmoud and Hosam Elbanna and Mahmoud Abdelnaby and Sameh Emile and Mohamed Anwar},
  title = {Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients},
  journal = {Journal of Surgery},
  volume = {6},
  number = {2},
  pages = {43-49},
  doi = {10.11648/j.js.20180602.13},
  url = {https://doi.org/10.11648/j.js.20180602.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20180602.13},
  abstract = {Bariatric surgery proved effective in the treatment of morbid obesity and its associated comorbidities. The aim of this study was to assess weight loss and changes in glucose homeostasis and satiety hormones and to evaluate improvement in diabetic status in morbidly obese patients with type two diabetes mellitus (T2DM) at 6 and 12 months after laparoscopic greater curvature plication (LGCP). Twenty patients with morbid obesity with T2DM were operated upon with LGCP. Weight loss was assessed by the decrease in BMI and percentage of excess weight loss at 6 and 12 months after LGCP. Fasting and postprandial blood glucose levels, HbA1c, fasting serum insulin, serum ghrelin and glucagon-like peptide 1 (GLP-1) levels were measured before and at 6 and 12 months postoperatively. The mean age of patients was 37.6 years. There was significant decrease in BMI from 45.4 to 40.1 at 6 months (p= 0.0008) and then to 36.4 at 12 month (p< 0.0001). The mean fasting blood glucose decreased significantly from 134.8 preoperatively to 120.8 at 6 months (p< 0.0001) and then to 109.5 at 12 months (p< 0.0001). The mean preoperative HbA1c declined from 6.8 before LGCO to 6.3 at 6 months (p< 0.0001) then to 5.9 at 12 months (p< 0.0001). The mean fasting insulin level decreased from 20.5 preoperatively to 17.4 at 6 months (p< 0.0001) then to 16.7 at 12 months (p< 0.0001). The mean baseline ghrelin level decreased significantly from 551.7 preoperatively to 441.5 at 6 months (p< 0.0001) then to 422.5 at 12 months (p< 0.0001). The mean GLP-1 declined from 33.7 before surgery to 33.5 at 6 months (p= 0.76) then to 33.1 at 12 months (p= 0.36). LGCP is an effective bariatric procedure that achieved satisfactory weight loss and significant improvement in the glycemic control as demonstrated by improvement in laboratory markers as serum glucose, insulin, and ghrelin hormone levels.},
 year = {2018}
}

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TY  - JOUR
T1  - Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients
AU  - Waleed Omar
AU  - Mohammad Hamed
AU  - Sabry Ahmed Mahmoud
AU  - Hosam Elbanna
AU  - Mahmoud Abdelnaby
AU  - Sameh Emile
AU  - Mohamed Anwar
Y1  - 2018/03/19
PY  - 2018
N1  - https://doi.org/10.11648/j.js.20180602.13
DO  - 10.11648/j.js.20180602.13
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 43
EP  - 49
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20180602.13
AB  - Bariatric surgery proved effective in the treatment of morbid obesity and its associated comorbidities. The aim of this study was to assess weight loss and changes in glucose homeostasis and satiety hormones and to evaluate improvement in diabetic status in morbidly obese patients with type two diabetes mellitus (T2DM) at 6 and 12 months after laparoscopic greater curvature plication (LGCP). Twenty patients with morbid obesity with T2DM were operated upon with LGCP. Weight loss was assessed by the decrease in BMI and percentage of excess weight loss at 6 and 12 months after LGCP. Fasting and postprandial blood glucose levels, HbA1c, fasting serum insulin, serum ghrelin and glucagon-like peptide 1 (GLP-1) levels were measured before and at 6 and 12 months postoperatively. The mean age of patients was 37.6 years. There was significant decrease in BMI from 45.4 to 40.1 at 6 months (p= 0.0008) and then to 36.4 at 12 month (p< 0.0001). The mean fasting blood glucose decreased significantly from 134.8 preoperatively to 120.8 at 6 months (p< 0.0001) and then to 109.5 at 12 months (p< 0.0001). The mean preoperative HbA1c declined from 6.8 before LGCO to 6.3 at 6 months (p< 0.0001) then to 5.9 at 12 months (p< 0.0001). The mean fasting insulin level decreased from 20.5 preoperatively to 17.4 at 6 months (p< 0.0001) then to 16.7 at 12 months (p< 0.0001). The mean baseline ghrelin level decreased significantly from 551.7 preoperatively to 441.5 at 6 months (p< 0.0001) then to 422.5 at 12 months (p< 0.0001). The mean GLP-1 declined from 33.7 before surgery to 33.5 at 6 months (p= 0.76) then to 33.1 at 12 months (p= 0.36). LGCP is an effective bariatric procedure that achieved satisfactory weight loss and significant improvement in the glycemic control as demonstrated by improvement in laboratory markers as serum glucose, insulin, and ghrelin hormone levels.
VL  - 6
IS  - 2
ER  -

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Author Information

Waleed Omar

General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt
Mohammad Hamed

General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt
Sabry Ahmed Mahmoud

General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt
Hosam Elbanna

General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt
Mahmoud Abdelnaby

General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt
Sameh Emile

General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt
Mohamed Anwar

General Surgery Department, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt

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APA Style

Waleed Omar, Mohammad Hamed, Sabry Ahmed Mahmoud, Hosam Elbanna, Mahmoud Abdelnaby, et al. (2018). Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients. Journal of Surgery, 6(2), 43-49. https://doi.org/10.11648/j.js.20180602.13

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ACS Style

Waleed Omar; Mohammad Hamed; Sabry Ahmed Mahmoud; Hosam Elbanna; Mahmoud Abdelnaby, et al. Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients. J. Surg. 2018, 6(2), 43-49. doi: 10.11648/j.js.20180602.13

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AMA Style

Waleed Omar, Mohammad Hamed, Sabry Ahmed Mahmoud, Hosam Elbanna, Mahmoud Abdelnaby, et al. Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients. J Surg. 2018;6(2):43-49. doi: 10.11648/j.js.20180602.13

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@article{10.11648/j.js.20180602.13,
  author = {Waleed Omar and Mohammad Hamed and Sabry Ahmed Mahmoud and Hosam Elbanna and Mahmoud Abdelnaby and Sameh Emile and Mohamed Anwar},
  title = {Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients},
  journal = {Journal of Surgery},
  volume = {6},
  number = {2},
  pages = {43-49},
  doi = {10.11648/j.js.20180602.13},
  url = {https://doi.org/10.11648/j.js.20180602.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20180602.13},
  abstract = {Bariatric surgery proved effective in the treatment of morbid obesity and its associated comorbidities. The aim of this study was to assess weight loss and changes in glucose homeostasis and satiety hormones and to evaluate improvement in diabetic status in morbidly obese patients with type two diabetes mellitus (T2DM) at 6 and 12 months after laparoscopic greater curvature plication (LGCP). Twenty patients with morbid obesity with T2DM were operated upon with LGCP. Weight loss was assessed by the decrease in BMI and percentage of excess weight loss at 6 and 12 months after LGCP. Fasting and postprandial blood glucose levels, HbA1c, fasting serum insulin, serum ghrelin and glucagon-like peptide 1 (GLP-1) levels were measured before and at 6 and 12 months postoperatively. The mean age of patients was 37.6 years. There was significant decrease in BMI from 45.4 to 40.1 at 6 months (p= 0.0008) and then to 36.4 at 12 month (p< 0.0001). The mean fasting blood glucose decreased significantly from 134.8 preoperatively to 120.8 at 6 months (p< 0.0001) and then to 109.5 at 12 months (p< 0.0001). The mean preoperative HbA1c declined from 6.8 before LGCO to 6.3 at 6 months (p< 0.0001) then to 5.9 at 12 months (p< 0.0001). The mean fasting insulin level decreased from 20.5 preoperatively to 17.4 at 6 months (p< 0.0001) then to 16.7 at 12 months (p< 0.0001). The mean baseline ghrelin level decreased significantly from 551.7 preoperatively to 441.5 at 6 months (p< 0.0001) then to 422.5 at 12 months (p< 0.0001). The mean GLP-1 declined from 33.7 before surgery to 33.5 at 6 months (p= 0.76) then to 33.1 at 12 months (p= 0.36). LGCP is an effective bariatric procedure that achieved satisfactory weight loss and significant improvement in the glycemic control as demonstrated by improvement in laboratory markers as serum glucose, insulin, and ghrelin hormone levels.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Evaluation of Weight Reduction, Diabetic State and Satiety Hormones After Laparoscopic Greater Curvature Plication in Morbidly Obese Diabetic Patients
AU  - Waleed Omar
AU  - Mohammad Hamed
AU  - Sabry Ahmed Mahmoud
AU  - Hosam Elbanna
AU  - Mahmoud Abdelnaby
AU  - Sameh Emile
AU  - Mohamed Anwar
Y1  - 2018/03/19
PY  - 2018
N1  - https://doi.org/10.11648/j.js.20180602.13
DO  - 10.11648/j.js.20180602.13
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 43
EP  - 49
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20180602.13
AB  - Bariatric surgery proved effective in the treatment of morbid obesity and its associated comorbidities. The aim of this study was to assess weight loss and changes in glucose homeostasis and satiety hormones and to evaluate improvement in diabetic status in morbidly obese patients with type two diabetes mellitus (T2DM) at 6 and 12 months after laparoscopic greater curvature plication (LGCP). Twenty patients with morbid obesity with T2DM were operated upon with LGCP. Weight loss was assessed by the decrease in BMI and percentage of excess weight loss at 6 and 12 months after LGCP. Fasting and postprandial blood glucose levels, HbA1c, fasting serum insulin, serum ghrelin and glucagon-like peptide 1 (GLP-1) levels were measured before and at 6 and 12 months postoperatively. The mean age of patients was 37.6 years. There was significant decrease in BMI from 45.4 to 40.1 at 6 months (p= 0.0008) and then to 36.4 at 12 month (p< 0.0001). The mean fasting blood glucose decreased significantly from 134.8 preoperatively to 120.8 at 6 months (p< 0.0001) and then to 109.5 at 12 months (p< 0.0001). The mean preoperative HbA1c declined from 6.8 before LGCO to 6.3 at 6 months (p< 0.0001) then to 5.9 at 12 months (p< 0.0001). The mean fasting insulin level decreased from 20.5 preoperatively to 17.4 at 6 months (p< 0.0001) then to 16.7 at 12 months (p< 0.0001). The mean baseline ghrelin level decreased significantly from 551.7 preoperatively to 441.5 at 6 months (p< 0.0001) then to 422.5 at 12 months (p< 0.0001). The mean GLP-1 declined from 33.7 before surgery to 33.5 at 6 months (p= 0.76) then to 33.1 at 12 months (p= 0.36). LGCP is an effective bariatric procedure that achieved satisfactory weight loss and significant improvement in the glycemic control as demonstrated by improvement in laboratory markers as serum glucose, insulin, and ghrelin hormone levels.
VL  - 6
IS  - 2
ER  -

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