The combination therapy of targeted anti-cancer drugs is important in the research of anti-cancer drugs. This articleintroduced the status of combination therapy of the same targeted and different targeted anti-cancer drugs, and analyzed the challenges and difficulties. In order to provide reference basis for development of combination therapy technique of targeted anti-cancer drugs in China.
Published in | Science Discovery (Volume 4, Issue 2) |
DOI | 10.11648/j.sd.20160402.17 |
Page(s) | 94-98 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
Cancer, Drug, Target, Combination Therapy
[1] | 世卫组织预计到2030年癌症死亡人数可能翻番,生物学通报,2010年第45卷第03期,25。 |
[2] | 胡胜等,癌症靶向药物的联合治疗,药品评价,2012年第9卷第21期,28-35。 |
[3] | Mendelsohn J, et al., Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol., 2003, 21(14): 2787-2799. |
[4] | 王勐等,厄洛替尼与西妥昔单抗联合应用治疗吉非替尼耐药N S C L C 的疗效,中国肿瘤临床,2011年第38卷第24期,1505-1509。 |
[5] | 韦玮等,西妥昔单抗联合厄洛替尼对人肝癌细胞的体外抑制作用,癌症,2008年第4期,386-392。 |
[6] | Miller KD, et al., Randomized phase Ⅲ trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer, J. Clin. Oncol., 2005, 23(4): 792-799. |
[7] | Blackwell KL, et al., Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer, J. Clin. Oncol., 2010, 28(7): 1124-1130. |
[8] | 江秉华 等,CN101332301A,2008年12月31日。 |
[9] | Wymann, M. P.,et al., Phosphoinositide 3-kinase signalling –which way to target Trends Pharmacol. Sci., 2003, 24(7): 366-376. |
[10] | Cantley, C. C., et al., New insights into tumor suppression: PTEN suppresses tumorformation by restraining the phosphoinositide 3-kinaseyAKT pathway, Proc. Natl. Acad. Sci., 1999, 96: 4240-4245. |
[11] | Engelman, J. A., Targeting PI3K signalling in cancer:opportunities, challenges andlimitations, Nature Reviews/Cancer, 2009, 9: 550-562. |
[12] | Kozma, S. C. et al., Regulation of cell size in growth,development and human disease:PI3K, PKB and S6K, Bioessays, 2002, 24: 65-71. |
[13] | Takeuchi H., et al., Synergistic Augmentation of Rapamycin-Induced Autophagyin Malignant Glioma Cells by Phosphatidylinositol3-Kinase/Protein Kinase B Inhibitors, Cancer Res., 2005, 65(8): 3336-3346. |
[14] | Sun S.Y., et al., Activation of Akt and eIF4E Survival Pathways byRapamycin-Mediated Mammalian Target of RapamycinInhibition, Cancer Res., 2005, 65(16): 7052-7058. |
[15] | BURSAVICH M., et al.,WO2006044453A1, 2006年4月27日。 |
[16] | GARCIA E. C.,et al.,WO2010049481A1, 2010年5月6日。 |
[17] | FRITSCH C., et al.,WO2012148846 A1, 2012年11月1日。 |
[18] | GUO X., et al.,WO2012148540 A1, 2012年11月1日。 |
[19] | B. Markman, et al., Status of PI3K inhibition and biomarker development in cancer therapeutics, Ann. Oncol., 2009, 21(4): 683-691. |
[20] | KLINGHOFFER R., et al.,WO2010120599 A2 2010年10月21日。 |
[21] | TAN J., et al.,WO2011084108 A1, 2011年7月14日。 |
[22] | LEE C. J., et al., WO2009036101A1, 2009年3月19日。 |
[23] | AFTAB D., et al., WO2008021389 A2,2008年2月21日。 |
[24] | FRITSCH C., et al., WO2010006225 A1, 2010年1月14日。 |
[25] | DUMBLE M., et al., WO2011038082 A1, 2011年3月31日。 |
[26] | DUMBLE M., et al., WO2011038085 A1, 2011年3月31日。 |
[27] | BEL V. M., et al., WO2011054620 A1, 2011年5月12日。 |
[28] | BIHONGNEU O. A., et al., WO2013037943 A1, 2013年3月21日。 |
[29] | GILMER T., et al., WO2011062930A1, 2011年5月26日。 |
APA Style
Jie Yang, Yan Wu, Zhen Wu, Yong-Tao Cui, Xiao-Qi Peng. (2016). Advances in the Combination Therapy of Targeted Anti-Cancer Drugs. Science Discovery, 4(2), 94-98. https://doi.org/10.11648/j.sd.20160402.17
ACS Style
Jie Yang; Yan Wu; Zhen Wu; Yong-Tao Cui; Xiao-Qi Peng. Advances in the Combination Therapy of Targeted Anti-Cancer Drugs. Sci. Discov. 2016, 4(2), 94-98. doi: 10.11648/j.sd.20160402.17
AMA Style
Jie Yang, Yan Wu, Zhen Wu, Yong-Tao Cui, Xiao-Qi Peng. Advances in the Combination Therapy of Targeted Anti-Cancer Drugs. Sci Discov. 2016;4(2):94-98. doi: 10.11648/j.sd.20160402.17
@article{10.11648/j.sd.20160402.17, author = {Jie Yang and Yan Wu and Zhen Wu and Yong-Tao Cui and Xiao-Qi Peng}, title = {Advances in the Combination Therapy of Targeted Anti-Cancer Drugs}, journal = {Science Discovery}, volume = {4}, number = {2}, pages = {94-98}, doi = {10.11648/j.sd.20160402.17}, url = {https://doi.org/10.11648/j.sd.20160402.17}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20160402.17}, abstract = {The combination therapy of targeted anti-cancer drugs is important in the research of anti-cancer drugs. This articleintroduced the status of combination therapy of the same targeted and different targeted anti-cancer drugs, and analyzed the challenges and difficulties. In order to provide reference basis for development of combination therapy technique of targeted anti-cancer drugs in China.}, year = {2016} }
TY - JOUR T1 - Advances in the Combination Therapy of Targeted Anti-Cancer Drugs AU - Jie Yang AU - Yan Wu AU - Zhen Wu AU - Yong-Tao Cui AU - Xiao-Qi Peng Y1 - 2016/05/18 PY - 2016 N1 - https://doi.org/10.11648/j.sd.20160402.17 DO - 10.11648/j.sd.20160402.17 T2 - Science Discovery JF - Science Discovery JO - Science Discovery SP - 94 EP - 98 PB - Science Publishing Group SN - 2331-0650 UR - https://doi.org/10.11648/j.sd.20160402.17 AB - The combination therapy of targeted anti-cancer drugs is important in the research of anti-cancer drugs. This articleintroduced the status of combination therapy of the same targeted and different targeted anti-cancer drugs, and analyzed the challenges and difficulties. In order to provide reference basis for development of combination therapy technique of targeted anti-cancer drugs in China. VL - 4 IS - 2 ER -