Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer

Ayman M. F. Elgohary; E. M. Ezz El-Arab

doi:doi:10.11648/j.sjc.20130101.11

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Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer

Ayman M. F. Elgohary, E. M. Ezz El-Arab

Published in Science Journal of Chemistry (Volume 1, Issue 1)

Published: 2 April 2013

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Abstract

A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL

Published in	Science Journal of Chemistry (Volume 1, Issue 1)
DOI	10.11648/j.sjc.20130101.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Pyrido[2,3-D][1,3]Oxazin-4-One, 2-Propylpyrido[2,3-D]Pyrimidin-4(3h)-One, Antitumor

References

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APA Style

Ayman M. F. Elgohary, E. M. Ezz El-Arab. (2013). Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Science Journal of Chemistry, 1(1), 1-6. https://doi.org/10.11648/j.sjc.20130101.11

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ACS Style

Ayman M. F. Elgohary; E. M. Ezz El-Arab. Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Sci. J. Chem. 2013, 1(1), 1-6. doi: 10.11648/j.sjc.20130101.11

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AMA Style

Ayman M. F. Elgohary, E. M. Ezz El-Arab. Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Sci J Chem. 2013;1(1):1-6. doi: 10.11648/j.sjc.20130101.11

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@article{10.11648/j.sjc.20130101.11,
  author = {Ayman M. F. Elgohary and E. M. Ezz El-Arab},
  title = {Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer},
  journal = {Science Journal of Chemistry},
  volume = {1},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.sjc.20130101.11},
  url = {https://doi.org/10.11648/j.sjc.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20130101.11},
  abstract = {A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL},
 year = {2013}
}

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TY  - JOUR
T1  - Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer
AU  - Ayman M. F. Elgohary
AU  - E. M. Ezz El-Arab
Y1  - 2013/04/02
PY  - 2013
N1  - https://doi.org/10.11648/j.sjc.20130101.11
DO  - 10.11648/j.sjc.20130101.11
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
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PB  - Science Publishing Group
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AB  - A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL
VL  - 1
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Author Information

Ayman M. F. Elgohary

Department of medical laboratories College of Applied Medical Science, Majmaah University, Almajma’ah 11952, KSA
E. M. Ezz El-Arab

National Organization For Drug Control & Research, Pharmaceutical Chemistry Division, Giza, Egypt

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APA Style

Ayman M. F. Elgohary, E. M. Ezz El-Arab. (2013). Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Science Journal of Chemistry, 1(1), 1-6. https://doi.org/10.11648/j.sjc.20130101.11

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ACS Style

Ayman M. F. Elgohary; E. M. Ezz El-Arab. Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Sci. J. Chem. 2013, 1(1), 1-6. doi: 10.11648/j.sjc.20130101.11

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AMA Style

Ayman M. F. Elgohary, E. M. Ezz El-Arab. Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer. Sci J Chem. 2013;1(1):1-6. doi: 10.11648/j.sjc.20130101.11

Copy | Download

@article{10.11648/j.sjc.20130101.11,
  author = {Ayman M. F. Elgohary and E. M. Ezz El-Arab},
  title = {Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer},
  journal = {Science Journal of Chemistry},
  volume = {1},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.sjc.20130101.11},
  url = {https://doi.org/10.11648/j.sjc.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20130101.11},
  abstract = {A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Green and Efficient Synthesis of Some Pyrido[2,3-D]Pyrimidin-4(3h)-One Derivatives Via Iodine Catalyst in Aqueous Media and Evaluation the Synthesized Compounds as Anticancer
AU  - Ayman M. F. Elgohary
AU  - E. M. Ezz El-Arab
Y1  - 2013/04/02
PY  - 2013
N1  - https://doi.org/10.11648/j.sjc.20130101.11
DO  - 10.11648/j.sjc.20130101.11
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20130101.11
AB  - A series of new 2-propylpyrido[2,3-d]pyrimidin-4(3H)-one with different substituents at position 3 were syn-thesized by traditional method and Iodine catalyst method. The effect of the newly synthesized compounds was tested as anti-cancer in National Cancer Institute(NCI)in USA. Some of the synthesized compounds exploited potent antitumor activity, especially the compounds pyrido[2,3-d][1,3]oxazin (2), 3-amino derivative 3a, 3b and hydroxy derivative 3c dis-played the highest activity among the test compounds with IC50 > 5 mg/mL
VL  - 1
IS  - 1
ER  -

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