The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction

Rongqin Dai; Zhenjiang Hou; Jingyu Zhang; Hong Fan; Hongsheng Wang; Jianzhang Hou

doi:doi:10.11648/j.sjph.20180602.14

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The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction

Rongqin Dai, Zhenjiang Hou, Jingyu Zhang, Hong Fan, Hongsheng Wang, Jianzhang Hou

Published in Science Journal of Public Health (Volume 6, Issue 2)

Received: 30 January 2018 Published: 5 February 2018

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Abstract

The objective is to discuss about the correlation of Glycolipid Metabolism, Cystatin C (CysC) and Homocysteine (Hcy) of thyroid dysfunction. 100 cases of hyperthyroidism, hypothyroidism and the control group are chose respectively to measure Fiber Bragg Grating (FBG), Blood Lipid, Thyroid Hormone (TH), CysC and Hcy, calculate the blood lipid ratio and make analysis. As a result, Thyroid Carcinoma (TC), Thyroglobulin (TG), Low-density Lipoprotein Cholesterol (LDL-C), High-density Lipoprotein Cholesterol (HDL-C), TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, Lipid comprehensive index (LCI) and non-HDL-C of hyperthyroidism group are obviously lower than the control group. The decrease of LCI is the most prominent. Hcy is slightly lower than the control group. FBG and CysC are obviously higher than the control group. TC, TG, LDL-C, TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C, Hcy of hypothyroidism group are higher than the control group (P＜0.05), and FBG, HDL-C and CysC are lower than the control group (P＜0.05). Various kinds of TH have the highest connection with TC, followed by non-HDL-C, LDL-C and LCI. It comes to the conclusion that patients with thyroid dysfunction easily appear the disorder of glucose and lipid metabolism. The change in blood lipid ratio is more pronounced than that of single lipid indicator and is closely related to CysC and Hcy. Dynamic monitoring of Thyroid Stimulating Hormone (TSH), blood lipid ratio, CysC and Hcy is of great value in the diagnosis of thyroid dysfunction and the prediction of Cardiovascular Disease (CVD) in concurrent Coronary Heart Disease (CHD) and so on.

Published in	Science Journal of Public Health (Volume 6, Issue 2)
DOI	10.11648/j.sjph.20180602.14
Page(s)	55-60
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Hyperthyroidism, Hypothyroidism, Blood Glucose, Blood Lipid Ratio, Cystain C, Homocysteine

References

[1]	Hou ZJ, Zhang JY, Mu ZX, et al. Screening analysis of positive thyroid autoantibody in waterborne high iodine area healthy people. Chinese Journal of Immunology, 2017, vol. 33, pp. 401-406.
[2]	Virgini VS, Wijsman LW, Rodondi N, et al. Subclinical thyroid dysfunction and functional capacity among elderly. Thyroid, 2014, vol. 24, pp. 208-214.
[3]	Hou ZJ, Hou JZ, Wang FL. Progress of Thyroid Diseases and Cardiovascular Disease Research. Medical Recapitulate, 2015, vol. 21, pp. 4296-4298.
[4]	Zhou CJ, Zhu XL, Wang CG, et al. The role of the combined detection of serum thyroid hormone and homocysteine in the diagnosis of hypothyroidism. Chinese Journal of Health Laboratory Technology, 2016, vol. 26, pp. 2205-2207.
[5]	Yang XD. Clinical study of abnormal metabolism of blood glucose and blood-fat in patients with hyperthyroidism and hypothyroidism. China Practical Medical, 2015, vol. 10, pp. 58-59.
[6]	Xu WD. Analysis of 112 hyperthyroidism patients complicated with metabolic disorder sugar and ester. China Tropical Medicine, 2009, vol. 9, pp. 1725, 1792.
[7]	Chen SM. The change and affecting factors of blood lipid and glucose level in pa-tients with subclinical thyroid dysfunction. China Modern Medicine, 2016, vol. 23, pp. 111-114.
[8]	Pan XY, Gu XM, Gong XH, et al. Effect of thyroid function on glycolipid metabolism. Journal of Wenzhou Medical University, 2011, vol. 41, pp. 274-276.
[9]	Selim FO, Ahmed AM. The association between serum paraxonase-1 activity, thyroid hormones and lipids profile in patients with primary hyperthyroidism. Int J Adv Res, 2014, vol. 2, pp. 172-181.
[10]	Wang Y, Ruan HL, Li Y, et al. Changes of thyroid function, autoantibodies, bone mineral density and bone metabolism indexes in patients with hyperthyroidism. Journal of Hainan Medical University, 2016, vol. 22, pp. 1418-1420.
[11]	Xiao L, Guo M, Fan RY. Study on the Relationship between Serum Lipid Metabolism and Thyroid Hormone Levels in Patients with Hyperthyroidism. Chinese Journal of Laboratory Diagnosis, 2016, vol. 20, pp. 1679-1681.
[12]	Sun JH, Zhang Y, Lu HR, et al. Correlation of serum adiponectin with thyroid dysfunction in elderly people. Laboratory Medicine, 2016, vol. 31, pp. 549-552.
[13]	Gu Q, Shao KK, Wang YX. Analysis of blood lipid and serum protein levels in patients with abnormal thyroid function. Laboratory Medicine and Clinic, 2014, vol. 11, pp. 3455-3456.
[14]	Zhang ZZ, Zhang HM, Fu XL. The relationship of the levels of thyroid hormone and atherosclerosis related factors of patients with hyperthyroidism. Chinese Journal of Difficult and Complicated Cases, 2015, vol. 15, pp. 926-930.
[15]	Zhao JJ, Yang LB. Hypothyroidism and dyslipidemia. Chinese Journal of Practical Internal Medicine, 2014, vol. 34, pp. 340-343.
[16]	Garduno-Garcia Jde J, Alvirde-Garcia U, Lopez-Carrasco G, et al. TSH and free thyroxine concentrations are associated with differing metabolic markers in euthyroid subjects. Eur J Endocrinol, 2010, vol. 163, pp. 273-278.
[17]	Fu YL, Fan LM. Progress in the study of the correlation between thyroid function and metabolic syndrome. Journal of Modern Medicine & Health, 2017, vol. 33, pp. 77-79.
[18]	Li F. The test and clinical significance of serum homocysteine and blood lipids in subclinical hypothyroidisn. Zhejiang Practical Medicine, 2009, vol. 14, pp. 366-367.
[19]	Song QZ, Xu FL, Bi XP, et al. Clinical significance of serum homocysteine and lipids determination in hypothyroidism. Laboratory Medicine, 2007, vol. 22, pp. 176-178.
[20]	Toruner F, Altinova AE, Karakoc A, et al. Risk factors for cardiovascu1ar disease in patients with subclinical hypothyroidism. Adv Ther, 2008, vol. 25, pp. 430~437.
[21]	Wang C, Zhang P. Clinical research progress of blood lipid ratio in predicting cardiovascular disease. Shandong Medical Journal, 2015, vol. 55, pp. 99-102.
[22]	Huang X, Cui ZW, Wu W, et al. The application of blood lipid ratio in the risk assessment of cardiovascular and cerebrovascular diseases. International Journal of Laboratory Medicine, 2015, vol. 36, pp. 1274-1276.
[23]	Xie YJ, The level and significance of blood lipid synthesis index in patients with different types of coronary heart disease. Contemporary Medicine, 2012, vol. 18, pp. 10-11.
[24]	Simprini LA, Villines TC, Rich M, et al. The relationship between subclinical atherosclerosis, non-high-density lipoprotein cholesterol, exercise and diet among male participants of the PACC project. J Clin Lipidol, 2012, vol. 6, pp. 174-179.
[25]	Chen XJ, Huang ZH. The value of non-high density lipoprotein cholesterol in predicting and evaluating the prognosis of coronary atherosclerotic heart disease. China Medical Engineering, 2016, vol. 24, pp. 53-55.
[26]	Ye Y, Gai X, Xie H, Jiao L, Zhang S. Impact of thyroid function on senlm cystatin C and estimated glomerular filtration rate：a cross-sectional study. Endocr Pract, 2013, vol. 19, pp. 397-403.
[27]	Xu YQ. Application of combined detection of serum cystatin C, creatinine and beta 2- microglobulin in thyroid dysfunction. The Journal of Medical Theory and Practice, 2015, vol. 28, pp. 953-954.
[28]	Yu WG, Liu Z, Zhang DF, et al. Meta-analysis of Relationship Between Serum Cystatin C Levels and Thyroid Function. Labeled Immunoassays and Clinical Medicine, 2016, vol. 23, pp. 579-582, 589.
[29]	Schmid C, Ghirlanda-Keller C, Zwimpfer C, et al. Triiodothyronine stimulates cystatin C production in bone cells. Biochem Biophys Res Commun, 2012, vol. 419, pp. 425-430.
[30]	Wang F, Pan W, Wang H, et al. The impacts of thyroid function on the diagnostic accuracy of cystatin C to detect acute kidney injury in ICU patients: a prospective, observational study. Crit Care, 2014, vol. 18, pp. R9.
[31]	Fricker M, Wiesli P, Brändle M, et al. Impact of thyroid dysfunction on serum cystatin C. Kidney Int, 2003, vol. 63, pp. 1944-1947.
[32]	Zhang D, Wang CX. Research progress of cystatin C in the clinical application of coronary heart disease. Medical Journal of West China, 2014, vol. 26, pp. 127-128, 131.
[33]	Jiang XJ, Chen XY, Chen H, et al. Effect of serum cystatin C on status of coronary atherosclerotic plaques. Practical Journal of Clinical Medicine, 2016, vol. 13, pp. 99-101.
[34]	Guan SK, Liu Z, Zhang FS, et al. A Meta-analysis on Relationship between Serum Cystatin C Level and Coronary Heart Disease. Labeled Immunoassays and Clinical Medicine, 2015, vol. 22, pp. 994-997.
[35]	Wu ZR, Zhang LR, Pan YQ, et al. Changes and clinical significance of serum homocysteine and lipids in Patients with primary hypothyroidism and hyperthyroid. Progress in Modern Biomedicine, 2009, vol. 9, pp. 4276-4278.
[36]	Yu WZ, Yuan D, Fan YX, et al. Correlation analysis of blood lipid, Homocysteine and Uric acid of patients with subclinical hypothyroidism. Chinese Journal of Laboratory Diagnosis, 2015, vol. 19, pp. 1496-1497.
[37]	Xiong L, Luo CD, Liu YB, et al. Changes of plasma homocysteine and peripheral arterial stiffness in subclinical hypothyroidism. West China Medical Journal, 2015, vol. 30, pp. 2205-2207.
[38]	Zhou Y, Chen Y, Cao X. Association between plasma homocysteine status and hypothyroidism：a meta- analysis. Int J Clin ExpMed, 2014, vol. 7, pp. 4544-4553.

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APA Style

Rongqin Dai, Zhenjiang Hou, Jingyu Zhang, Hong Fan, Hongsheng Wang, et al. (2018). The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction. Science Journal of Public Health, 6(2), 55-60. https://doi.org/10.11648/j.sjph.20180602.14

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ACS Style

Rongqin Dai; Zhenjiang Hou; Jingyu Zhang; Hong Fan; Hongsheng Wang, et al. The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction. Sci. J. Public Health 2018, 6(2), 55-60. doi: 10.11648/j.sjph.20180602.14

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AMA Style

Rongqin Dai, Zhenjiang Hou, Jingyu Zhang, Hong Fan, Hongsheng Wang, et al. The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction. Sci J Public Health. 2018;6(2):55-60. doi: 10.11648/j.sjph.20180602.14

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@article{10.11648/j.sjph.20180602.14,
  author = {Rongqin Dai and Zhenjiang Hou and Jingyu Zhang and Hong Fan and Hongsheng Wang and Jianzhang Hou},
  title = {The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction},
  journal = {Science Journal of Public Health},
  volume = {6},
  number = {2},
  pages = {55-60},
  doi = {10.11648/j.sjph.20180602.14},
  url = {https://doi.org/10.11648/j.sjph.20180602.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20180602.14},
  abstract = {The objective is to discuss about the correlation of Glycolipid Metabolism, Cystatin C (CysC) and Homocysteine (Hcy) of thyroid dysfunction. 100 cases of hyperthyroidism, hypothyroidism and the control group are chose respectively to measure Fiber Bragg Grating (FBG), Blood Lipid, Thyroid Hormone (TH), CysC and Hcy, calculate the blood lipid ratio and make analysis. As a result, Thyroid Carcinoma (TC), Thyroglobulin (TG), Low-density Lipoprotein Cholesterol (LDL-C), High-density Lipoprotein Cholesterol (HDL-C), TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, Lipid comprehensive index (LCI) and non-HDL-C of hyperthyroidism group are obviously lower than the control group. The decrease of LCI is the most prominent. Hcy is slightly lower than the control group. FBG and CysC are obviously higher than the control group. TC, TG, LDL-C, TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C, Hcy of hypothyroidism group are higher than the control group (P＜0.05), and FBG, HDL-C and CysC are lower than the control group (P＜0.05). Various kinds of TH have the highest connection with TC, followed by non-HDL-C, LDL-C and LCI. It comes to the conclusion that patients with thyroid dysfunction easily appear the disorder of glucose and lipid metabolism. The change in blood lipid ratio is more pronounced than that of single lipid indicator and is closely related to CysC and Hcy. Dynamic monitoring of Thyroid Stimulating Hormone (TSH), blood lipid ratio, CysC and Hcy is of great value in the diagnosis of thyroid dysfunction and the prediction of Cardiovascular Disease (CVD) in concurrent Coronary Heart Disease (CHD) and so on.},
 year = {2018}
}

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TY  - JOUR
T1  - The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction
AU  - Rongqin Dai
AU  - Zhenjiang Hou
AU  - Jingyu Zhang
AU  - Hong Fan
AU  - Hongsheng Wang
AU  - Jianzhang Hou
Y1  - 2018/02/05
PY  - 2018
N1  - https://doi.org/10.11648/j.sjph.20180602.14
DO  - 10.11648/j.sjph.20180602.14
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 55
EP  - 60
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20180602.14
AB  - The objective is to discuss about the correlation of Glycolipid Metabolism, Cystatin C (CysC) and Homocysteine (Hcy) of thyroid dysfunction. 100 cases of hyperthyroidism, hypothyroidism and the control group are chose respectively to measure Fiber Bragg Grating (FBG), Blood Lipid, Thyroid Hormone (TH), CysC and Hcy, calculate the blood lipid ratio and make analysis. As a result, Thyroid Carcinoma (TC), Thyroglobulin (TG), Low-density Lipoprotein Cholesterol (LDL-C), High-density Lipoprotein Cholesterol (HDL-C), TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, Lipid comprehensive index (LCI) and non-HDL-C of hyperthyroidism group are obviously lower than the control group. The decrease of LCI is the most prominent. Hcy is slightly lower than the control group. FBG and CysC are obviously higher than the control group. TC, TG, LDL-C, TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C, Hcy of hypothyroidism group are higher than the control group (P＜0.05), and FBG, HDL-C and CysC are lower than the control group (P＜0.05). Various kinds of TH have the highest connection with TC, followed by non-HDL-C, LDL-C and LCI. It comes to the conclusion that patients with thyroid dysfunction easily appear the disorder of glucose and lipid metabolism. The change in blood lipid ratio is more pronounced than that of single lipid indicator and is closely related to CysC and Hcy. Dynamic monitoring of Thyroid Stimulating Hormone (TSH), blood lipid ratio, CysC and Hcy is of great value in the diagnosis of thyroid dysfunction and the prediction of Cardiovascular Disease (CVD) in concurrent Coronary Heart Disease (CHD) and so on.
VL  - 6
IS  - 2
ER  -

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Author Information

Rongqin Dai

Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Zhenjiang Hou

Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Jingyu Zhang

Laboratory Diagnostics Division, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Hong Fan

Laboratory Diagnostics Division, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Hongsheng Wang

Laboratory Diagnostics Division, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Jianzhang Hou

Department of Surgery, Cangzhou Medical College Hospital District of Cangzhou People's Hospital, Cangzhou, China

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APA Style

Rongqin Dai, Zhenjiang Hou, Jingyu Zhang, Hong Fan, Hongsheng Wang, et al. (2018). The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction. Science Journal of Public Health, 6(2), 55-60. https://doi.org/10.11648/j.sjph.20180602.14

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ACS Style

Rongqin Dai; Zhenjiang Hou; Jingyu Zhang; Hong Fan; Hongsheng Wang, et al. The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction. Sci. J. Public Health 2018, 6(2), 55-60. doi: 10.11648/j.sjph.20180602.14

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AMA Style

Rongqin Dai, Zhenjiang Hou, Jingyu Zhang, Hong Fan, Hongsheng Wang, et al. The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction. Sci J Public Health. 2018;6(2):55-60. doi: 10.11648/j.sjph.20180602.14

Copy | Download

@article{10.11648/j.sjph.20180602.14,
  author = {Rongqin Dai and Zhenjiang Hou and Jingyu Zhang and Hong Fan and Hongsheng Wang and Jianzhang Hou},
  title = {The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction},
  journal = {Science Journal of Public Health},
  volume = {6},
  number = {2},
  pages = {55-60},
  doi = {10.11648/j.sjph.20180602.14},
  url = {https://doi.org/10.11648/j.sjph.20180602.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20180602.14},
  abstract = {The objective is to discuss about the correlation of Glycolipid Metabolism, Cystatin C (CysC) and Homocysteine (Hcy) of thyroid dysfunction. 100 cases of hyperthyroidism, hypothyroidism and the control group are chose respectively to measure Fiber Bragg Grating (FBG), Blood Lipid, Thyroid Hormone (TH), CysC and Hcy, calculate the blood lipid ratio and make analysis. As a result, Thyroid Carcinoma (TC), Thyroglobulin (TG), Low-density Lipoprotein Cholesterol (LDL-C), High-density Lipoprotein Cholesterol (HDL-C), TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, Lipid comprehensive index (LCI) and non-HDL-C of hyperthyroidism group are obviously lower than the control group. The decrease of LCI is the most prominent. Hcy is slightly lower than the control group. FBG and CysC are obviously higher than the control group. TC, TG, LDL-C, TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C, Hcy of hypothyroidism group are higher than the control group (P＜0.05), and FBG, HDL-C and CysC are lower than the control group (P＜0.05). Various kinds of TH have the highest connection with TC, followed by non-HDL-C, LDL-C and LCI. It comes to the conclusion that patients with thyroid dysfunction easily appear the disorder of glucose and lipid metabolism. The change in blood lipid ratio is more pronounced than that of single lipid indicator and is closely related to CysC and Hcy. Dynamic monitoring of Thyroid Stimulating Hormone (TSH), blood lipid ratio, CysC and Hcy is of great value in the diagnosis of thyroid dysfunction and the prediction of Cardiovascular Disease (CVD) in concurrent Coronary Heart Disease (CHD) and so on.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - The Correlation Analysis on Glycolipid Metabolism, CysC and Homocysteine of Thyroid Dysfunction
AU  - Rongqin Dai
AU  - Zhenjiang Hou
AU  - Jingyu Zhang
AU  - Hong Fan
AU  - Hongsheng Wang
AU  - Jianzhang Hou
Y1  - 2018/02/05
PY  - 2018
N1  - https://doi.org/10.11648/j.sjph.20180602.14
DO  - 10.11648/j.sjph.20180602.14
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 55
EP  - 60
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20180602.14
AB  - The objective is to discuss about the correlation of Glycolipid Metabolism, Cystatin C (CysC) and Homocysteine (Hcy) of thyroid dysfunction. 100 cases of hyperthyroidism, hypothyroidism and the control group are chose respectively to measure Fiber Bragg Grating (FBG), Blood Lipid, Thyroid Hormone (TH), CysC and Hcy, calculate the blood lipid ratio and make analysis. As a result, Thyroid Carcinoma (TC), Thyroglobulin (TG), Low-density Lipoprotein Cholesterol (LDL-C), High-density Lipoprotein Cholesterol (HDL-C), TC/HDL-C, TG/HDL-C, LDL-C/HDL-C, Lipid comprehensive index (LCI) and non-HDL-C of hyperthyroidism group are obviously lower than the control group. The decrease of LCI is the most prominent. Hcy is slightly lower than the control group. FBG and CysC are obviously higher than the control group. TC, TG, LDL-C, TG/HDL-C, LDL-C/HDL-C, LCI and non-HDL-C, Hcy of hypothyroidism group are higher than the control group (P＜0.05), and FBG, HDL-C and CysC are lower than the control group (P＜0.05). Various kinds of TH have the highest connection with TC, followed by non-HDL-C, LDL-C and LCI. It comes to the conclusion that patients with thyroid dysfunction easily appear the disorder of glucose and lipid metabolism. The change in blood lipid ratio is more pronounced than that of single lipid indicator and is closely related to CysC and Hcy. Dynamic monitoring of Thyroid Stimulating Hormone (TSH), blood lipid ratio, CysC and Hcy is of great value in the diagnosis of thyroid dysfunction and the prediction of Cardiovascular Disease (CVD) in concurrent Coronary Heart Disease (CHD) and so on.
VL  - 6
IS  - 2
ER  -

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